2021.10.20 17:39 postmastern Созданы сперматозоиды из стволовых клеток примато. Американские ученые утверждают, что их исследование может помочь в разработке лечения бесплодия у людей.
Созданы сперматозоиды из стволовых клеток приматов / ©Getty images
Считается, что с проблемой бесплодия сталкиваются около 15 процентов семейных пар. Примерно 20-30 процентов таких случаев связаны с неспособностью организма мужчины производить жизнеспособные сперматозоиды. Идея о выращивании половых клеток из собственного биоматериала — то, на что направлены взоры ученых для решения проблемы.
Несколько лет назад китайские исследователи продемонстрировали возможность получения таких сперматозоидов на мышах. Полноценные мужские клетки вырастили на основе эмбриональных стволовых: ими оплодотворили яйцеклетки мышей, а те после этого дали здоровое потомство. Но для людей все сложнее — процесс развития сперматозоидов происходит у нас дольше и сложнее.
На этот раз ученые из Национального исследовательского центра приматов Йеркса (США) впервые показали, что функциональные сперматозоиды можно вырастить с использованием эмбриональных стволовых клеток приматов. Результаты работы они опубликовали00066-5/fulltext?_ga=2.224582746.1553878625.1634711362-1149337666.1634711362#%20) в журнале Fertility and Sterility Science.
Для получения незрелых сперматозоидов, которых называют круглыми сперматидами, авторы работы использовали эмбриональные стволовые клетки макак-резусов. Ученые показали, что они способны оплодотворить яйцеклетку обезьяны. По мнению исследователей, это первый шаг к переводу такой технологии для людей, поскольку, в отличие от мышей, репродуктивные механизмы макак-резусов схожи с человеческими.
Следующий этап исследований — имплантация получившихся эмбрионов суррогатной макаке. Так специалисты планируют проверить, могут ли зародыши от таких сперматид развиться в здоровое потомство. Этим намерены заняться в ближайшее время.
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2021.10.20 17:39 benetonr [FS] [UK] [UK] Ann Demeulemeester 6cm back lace boots - 39
Ann Demeulemeester back lace boots with 6cm heel from Player Shoes, size 39. They fit larger so can accommodate sizes from 39-41. Personally I am a 40 and wore with two pairs of socks.
Wore in total for about a week, slight sign of heel wear and clear creasing. Will clean up before sending.
£90 posted within the UK.
Open to offers. Open to international.
PAYPAL INVOICE. Tagged in imgur.
Please PM / chat!
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2021.10.20 17:39 trottta Pablo terá contrato ampliado e aumento de salário; entenda por quê
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2021.10.20 17:39 Skin_Head_Ting Behz was at my rugby game today... no clue why but he was there (faces blurred for privacy)
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2021.10.20 17:39 sjyounis Video Clip From Last Night's "Supergirl" Episode "Nightmare in National City"
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2021.10.20 17:39 Due-Imagination3837 chara erased the title
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2021.10.20 17:39 Guonejo_1313 Low FPS in any games
Hello everyone, I recently upgraded to Windows 11 and when playing games I have less FPS than I used to with Windows 10, there are some moments when the keyboard and mouse are not responding and I have to disconnect and reconnect (I thought it was the problem of the HyperX software, but it is clearly a problem with OS) Any solution regarding this?
I have even lost FPS in League of Legends, I usually have a stable 120fps, now I have between 80-90fps; With Battlefield V in 45fps medium graphics, in addition to the loss of response of the peripherals.
This is my PC Specs:
MoBo: Asrock B450 Steel Legend CPU: AMD Ryzen 5 2600X RAM: 8x2 GB Crucial Ballistix 3000Mhz HDD: Seagate Barracuda 1TB SSD: Kingston 240GB A100 GPU: Nvidia RTX 2060 Gigabyte OC Case: Aorus C300 Glass Mousepad: HyperX Fury XXL Mouse: HyperX Pulsefire Surge Headset: HyperX Cloud Alpha Teclado: HyperX Alloy Origins HyperX Switch Blue Microphone: HyperX Quadcast.
(I copied and pasted from my twitch channel description)
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2021.10.20 17:39 ILikePracticalGifts Bitcoin pulling back. I’m scared…
2021.10.20 17:39 Ryvn_Tvylor "Sometimes you're flush and sometimes you're bust, and when you're up, it's never as good as it seems, and when you're down, you never think you'll be up again, but life goes on."
2021.10.20 17:39 NSAirsofter Today's haul.
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2021.10.20 17:39 Teleione Κανένας από Ελλάδα να μας χορηγήσει ? :)
2021.10.20 17:39 Coach-Past CLOV Stock trading “HODL” Short Squeeze Graphical
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2021.10.20 17:39 the-glottal-stop Why do my converse destroy all my socks?
I recently got the classic chuck taylors, the high rise ones. Every time I wear them, they rip up my socks where my Achilles heel is. I then have to throw those socks away. Why is that happening? How do I get it to stop?
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2021.10.20 17:39 ic22487 Found in a park in the NW Dallas Area - any id?
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2021.10.20 17:39 reynhout galliumos.org and mrchromebox.tech temporarily unavailable
We are migrating all services to a new server.
This will require a few (hopefully) brief outages while snapshots are made from quiescent filesystems, and then some variability due to DNS propagation.
This post will be updated when the transition is complete.
Thanks for your patience!
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2021.10.20 17:39 The-Eggster Constipation is a curse
So due to blood pressure medication I get constipated quite often, and it’s been manageable through various ways. One thing I’ve always been bad at is straining too hard, and I know how terrible that is on your bowels and other things.
Six days ago I got really constipated and had big/hard pebble stools, so I started MiraLAX and upped my water intake to support softer stools. Over the course of three days nothing came out even with a lot of exercise and everything else I was doing, plus I was also getting pain in my left abdominal area and felt nauseous. So I tried a mineral enema and a bunch of long narrow stools came out which looked soft but had circular patches of red blood on areas throughout.
I’ve dealt with constipation before but nothing like this, so I went to A&E since my GP is useless and the doctor there did an x-ray and afterwards performed a quick/aggressive rectal exam (which hurt). He told me it’s probably just due to constipation and the stool that was sitting there (which is why it supposedly hurts there) and maybe internal hemorrhoids, but I explained to him the narrow stools are soft now and I’m still able to go now but he just said it’s nothing to worry about.
An x-ray is only decent for showing blockages, and while I guess that’s good impactation is checked off that doesn’t give a good picture of bowel health. I wish I could get a sigmoidoscopy but they wouldn’t do it, because my problems aren’t severe even though two days after seeing him I still have pain in the exact same spot, stools are extremely narrow, there’s constant gas, and it feels like I have to go to the toilet.
Considering my stools have always been at least normal size and have recently been having regular every day or two, and now they’re long and small, I’m concerned it’s something like cancer, narrowing of the bowels, or something serious to cause major damage.
I just don’t know where to proceed from here, as the health care system in Canada is a bloody joke, and most doctors don’t want to do the more “expensive” tests and have even told that to my face. Has anyone else been having trouble with getting doctors to believe your symptoms of constipation warrant a looking at?
It took a lot of courage to even go to that hospital, and now that I may have to go again is weighing on my mind.
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2021.10.20 17:39 sheakspeares Why do you think Twitter is the most toxic social media platform?
2021.10.20 17:39 LeeroyM The Forest Witch.
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2021.10.20 17:39 DEF_CON_ONE New subreddit dedicated to Manifest's own Parveen Kaur aka Dr. Saanvi Bahl!
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2021.10.20 17:39 allthekos Yesterday was really warm, so I wore my big coat and was sweating. So today I wore my light jacket and it was torrential rain and freezing cold.
2021.10.20 17:39 verydeeptruthbringer Sur rune
2021.10.20 17:39 Gnome_Sane If you make $10,000 in income from another source than your wages, or if you spend $10,000 more than your wage income, the IRS want's your bank to rat you out legally. So if you make 10K a year under the table selling comics, antiques, plowing driveways, Bartend and keep tips... Any Reason.
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2021.10.20 17:39 Clouding_Akuma Got this weapon for a while and only now realized i had it but on which theresa outfit should i give it to?
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2021.10.20 17:39 youngluck BATTLE ROUND 4: HOST
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2021.10.20 17:39 Sami_1999 Dismembered Necromorphs should still twitch every now and then
I think the original game and trilogy didn't had this due to limitations of those old hardwares. But the dismembered necromorphs should still twitch on the ground on the remake.
They did that on the animated movie and books. Also on higher difficulties, we shouldn't be able to kill them off by just dismembering one leg and a hand like the originals. Lore wise it seems like necromorphs should still chase you.
Even if they bleed and get incapacitate, it should take a while to bleed out. Body shot spam shouldn't stagger them that much and they should still proceed towards the players slowly and if we do kill them with body shots, their body should get ripped in half or several pieces. And if we shoot them a lot [which would count as killing necros in the original game] but dont manage to dismember the limbs or rip their body apart, then the necromorphs should just get stunned and knocked down temporarily. This is also something we saw in the animated film where one of them just dropped on the ground without any guarantee of it dying.
So I'm not saying enough body shots shouldn't kill them at all, but that it should be inefficient and drain out ammo by a lot [to the point where we might get screwed for lack of ammo] and body shot kills should have at least some form of visual feedback so that it looks convincing enough that we ripped the body apart.
Also there were over hundred of people in Ishimura. It will be nice to have multiple faces for necromorphs even if the body model is same. The head model or texture can be different to add variety and give the feeling that these necromorphs were different people and were alive just like the player once. Obviously not expecting 1000s of different head models, but we need a lot more face variety than we had in the original game.
Things like this will make the remake more meaningful than just a graphical upgrade.
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